Pharmaceutical diversification via palladium oxidative addition complexes
نویسندگان
چکیده
منابع مشابه
Synthesis of heterocycles via palladium-catalyzed oxidative addition.
Palladium-catalyzed processes have proven to be a powerful and useful tool for the synthesis of heterocycles. Palladium has found such wide utility because it affects an extraordinary number of very different reactions, including many carbon-carbon bond-forming reactions, under relatively mild reaction conditions. Furthermore, palladium can usually be used in only catalytic amounts and tolerate...
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Bis-N-heterocyclic carbenes Pd0 complexes, Pd(NHC)2, are efficient catalysts in Heck reactions performed with aryl bromides or chlorides. The Pd(NHC)2 that are not stable are generated in situ from PdII precursors PdY2(NHC)2 (Y = halides) after a chemical reduction. The latter procedure can be mimicked by an electrochemical reduction. The transient Pd(NHCBn)2 is generated by electrochemical red...
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Density functional theory has been used to investigate various solvated species that may be formed from palladium bis N-heterocyclic carbene complexes, [Pd(cyclo-C{NRCH}2)2], (PdL2) in benzene solution. Formation of an g -arene complex is shown to stabilise a monocarbene species, PdL(g-C6H5X), where the arene is either the solvent or a reacting aryl halide. Oxidative addition of an aryl chlorid...
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The manifold of reaction pathways for the oxidative addition of phenyl bromide and phenyl chloride substrates to phosphine-modified palladium(0) complexes has been investigated with dispersion-corrected density functional theory (B3LYP-D2) for a range of synthetically relevant ligands, permitting the evaluation of ligand, substrate and method effects on calculated predictions. Bulky and electro...
متن کاملTrinuclear palladium addition to unsaturated carbocycles.
The trinuclear palladium addition to monocyclic unsaturated hydrocarbons was revealed. The trinuclear adduct of [2.2]paracyclophane, cycloheptatriene (CHT), or cyclooctatetraene (COT) was obtained by treatment of the corresponding tripalladium sandwich complexes with 3 equiv. of 1,10-phenanthroline. In the trinuclear adduct of [2.2]paracyclophane or CHT, a Pd2 unit and a Pd1 unit synfacially co...
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ژورنال
عنوان ژورنال: Science
سال: 2019
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aac6153